Syn-Ake

SYN-AKE is a synthetic tripeptide mimicking the neuromuscular blocking activity of waglerin-1, a peptide toxin from the temple viper (Tropidolaemus wagleri). Developed by Pentapharm (DSM), it acts as a reversible antagonist of the muscular nicotinic acetylcholine receptor (nAChR), reducing facial muscle contraction and smoothing expression wrinkles. Clinical studies show up to 52% wrinkle reduction after 28 days of topical application. Unlike botulinum toxin which blocks neurotransmitter release, SYN-AKE blocks the postsynaptic response — a distinct mechanism that provides partial, reversible muscle relaxation.

SYN-AKE competitively antagonizes the muscle-type nicotinic acetylcholine receptor (α1β1δε nAChR) at the neuromuscular junction. By blocking acetylcholine binding on the postsynaptic (muscle) side, it reduces end-plate potential amplitude and muscle contraction force. The effect is reversible and partial, producing relaxation without complete paralysis.

Anti-Wrinkle Cosmeceutical Clinical studies demonstrate 52% wrinkle reduction at 4% concentration after 28 days. Most effective for forehead and periorbital wrinkles. Topical Muscle Relaxant Research Studied as a topical approach to reduce expression line formation.

Competitive antagonism at α1-subunit nAChR binding site. Reduced end-plate potential. Partial neuromuscular blockade.

Well-tolerated topically. No systemic absorption at cosmetic concentrations. Rare mild skin irritation.

Stable in cosmetic formulations. Store at room temperature. Compatible with standard cosmetic ingredients and formulations.

Approved cosmetic ingredient (INCI: Dipeptide Diaminobutyroyl Benzylamide Diacetate). Used in commercial anti-aging products.