Syn-Ake molecular structure
Syn-Ake molecular structure
Approved
🧴Cosmetic & Topical

Syn-Ake

Also known as: Dipeptide Diaminobutyroyl Benzylamide Diacetate

MW

474.60 Da

Formula

C22H38N4O4S2

CAS

823202-99-9

Routes

1 route

SYN-AKE is a synthetic tripeptide mimicking the neuromuscular blocking activity of waglerin-1, a peptide toxin from the temple viper (Tropidolaemus wagleri). Developed by Pentapharm (DSM), it acts as a reversible antagonist of the muscular nicotinic acetylcholine receptor (nAChR), reducing facial muscle contraction and smoothing expression wrinkles. Clinical studies show up to 52% wrinkle reduction after 28 days of topical application. Unlike botulinum toxin which blocks neurotransmitter release, SYN-AKE blocks the postsynaptic response — a distinct mechanism that provides partial, reversible muscle relaxation.

Research Use Only— For educational and research purposes only

Research Applications

Anti-Wrinkle Cosmeceutical

Clinical studies demonstrate 52% wrinkle reduction at 4% concentration after 28 days. Most effective for forehead and periorbital wrinkles.

Topical Muscle Relaxant Research

Studied as a topical approach to reduce expression line formation.

Mechanism of Action

SYN-AKE competitively antagonizes the muscle-type nicotinic acetylcholine receptor (α1β1δε nAChR) at the neuromuscular junction. By blocking acetylcholine binding on the postsynaptic (muscle) side, it reduces end-plate potential amplitude and muscle contraction force. The effect is reversible and partial, producing relaxation without complete paralysis.

Biological Pathways

Competitive antagonism at α1-subunit nAChR binding site. Reduced end-plate potential. Partial neuromuscular blockade.

Dosage Information

Typical dosage ranges for research applications. Always verify with current literature.
Frequency
Once or twice daily as serum/cream (4% concentration)
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Calculation Results

Concentration
2.5 mg/ml
Dose Volume
0.1 ml0.100 ml
Insulin Syringe
10 units
Doses per Vial
2020 doses @ 250 mcg

Syringe Fill Level (100u syringe)

05010010.0uunits
0u10.0 / 100 units (10%)100u

Protocols

No protocols featuring this peptide yet.

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Stability & Storage

Stable in cosmetic formulations. Store at room temperature. Compatible with standard cosmetic ingredients and formulations.

Side Effects & Precautions

Well-tolerated topically. No systemic absorption at cosmetic concentrations. Rare mild skin irritation.

Research Use Only. This information is for educational and research purposes only. Not intended for medical advice or self-medication.

Regulatory Status

Approved

Approved cosmetic ingredient (INCI: Dipeptide Diaminobutyroyl Benzylamide Diacetate). Used in commercial anti-aging products.

Research Studies

SYN-AKE: A Peptide Mimicking Waglerin-1 for Expression Line Reduction

Pentapharm DSM Technical Documentation.

International Journal of Cosmetic Science
2009
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