Matrixyl molecular structure
Matrixyl molecular structure
Approved
🧴Cosmetic & Topical

Matrixyl

Also known as: Palmitoyl Pentapeptide-4, Pal-KTTKS

MW

578.71 Da

Formula

C26H47N5O6

CAS

214047-00-4

Routes

1 route

Matrixyl (palmitoyl pentapeptide-4, Pal-KTTKS) is a lipopeptide developed by Sederma that stimulates collagen and extracellular matrix production in skin fibroblasts. It is based on a pentapeptide fragment (KTTKS) of type I procollagen that acts as a matrikine — a peptide derived from extracellular matrix breakdown that signals fibroblasts to synthesize new matrix components. The palmitoyl chain enhances skin penetration and cellular uptake. Clinical studies demonstrate improvements in wrinkle depth and skin texture comparable to retinol but without irritation. Matrixyl 3000 (palmitoyl tripeptide-1 + palmitoyl tetrapeptide-7) and Matrixyl Synthe'6 are subsequent generations with enhanced activity.

Research Use Only— For educational and research purposes only

Research Applications

Anti-Aging Skincare

Clinical trials demonstrate 68% reduction in wrinkle depth after 2 months of twice-daily application. Promotes collagen I and III synthesis by up to 350% in vitro.

Wound Healing

Matrikine signaling accelerates dermal repair.

Mechanism of Action

The KTTKS sequence acts as a matrikine signal — when detected by fibroblast TGF-β receptors and integrins, it triggers the cell to upregulate collagen synthesis (types I, III, IV), fibronectin, and hyaluronic acid production. The palmitoyl chain facilitates penetration through the stratum corneum and anchoring in the cell membrane, enhancing intracellular delivery of the active pentapeptide.

Biological Pathways

TGF-β/Smad signaling for collagen gene transcription. Integrin-mediated mechanotransduction. HSP47 upregulation for collagen folding and secretion.

Dosage Information

Typical dosage ranges for research applications. Always verify with current literature.
Frequency
Once or twice daily as serum/cream
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Calculation Results

Concentration
2.5 mg/ml
Dose Volume
0.1 ml0.100 ml
Insulin Syringe
10 units
Doses per Vial
2020 doses @ 250 mcg

Syringe Fill Level (100u syringe)

05010010.0uunits
0u10.0 / 100 units (10%)100u

Protocols

Anti-Aging Skincare Peptide Stack
Beginner
✨Skin & Beauty
Ongoing (8-12 weeks for visible results)

Topical peptide protocol for wrinkle reduction, collagen stimulation, and skin rejuvenation.

Dosage
Matrixyl serum (morning), Argireline serum (evening), GHK-Cu (night)
Frequency
Matrixyl: AM after cleansing. Argireline: PM on expression lines. GHK-Cu: PM after Argireline.
Cycle
Continuous use. Results visible after 8-12 weeks of consistent application.
Stacking Notes
Apply to clean skin. Layer from thinnest to thickest. Use sunscreen daily. Can add oral collagen (10g daily) for enhanced effects.

Warning: Patch test first. Rare sensitivity possible.

View Full Protocol

Stability & Storage

Stable in cosmetic formulations at pH 5-7. Store at room temperature. Compatible with most cosmetic ingredients. The palmitoyl chain provides lipophilic stability.

Side Effects & Precautions

Excellent safety profile. No irritation at standard concentrations (2-8%). Non-sensitizing. Suitable for sensitive skin.

Research Use Only. This information is for educational and research purposes only. Not intended for medical advice or self-medication.

Regulatory Status

Approved

Approved cosmetic ingredient (INCI: Palmitoyl Pentapeptide-4). Widely used in commercial anti-aging skincare.

Research Studies

Stimulation of Collagen Synthesis by Pal-KTTKS Pentapeptide

Katayama K, Armendariz-Borunda J, Raghow R, et al.

Journal of Biological Chemistry
1993
View Source

Clinical Assessment of Palmitoyl Pentapeptide-4

Robinson LR, Fitzgerald NC, Pelvit DG, et al.

International Journal of Cosmetic Science
2005
View Source
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