Research Applications
Circadian rhythm restoration. Age-related melatonin decline. Sleep disorders. Neuroprotection via melatonin pathway.
Mechanism of Action
Pinealon interacts with DNA regulatory elements in pinealocytes, upregulating enzymes involved in melatonin biosynthesis from serotonin. It normalizes circadian clock gene expression and enhances nocturnal melatonin peaks.
Biological Pathways
Pineal gland support, Circadian rhythm, Sleep regulation
Dosage Information
Calculation Results
Syringe Fill Level (100u syringe)
Protocols
No protocols featuring this peptide yet.
Browse All ProtocolsSide Effects & Precautions
Minimal reported
Research Use Only. This information is for educational and research purposes only. Not intended for medical advice or self-medication.
Research Studies
Pinealon Regulates Melatonin Synthesis
Khavinson VK, Linkova NS.
Frequently Asked Questions
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed as a pineal gland bioregulator by the Khavinson group. It is designed to normalize melatonin synthesis and circadian rhythm function. Preclinical studies demonstrate that pinealon can penetrate cell membranes and nuclear membranes, interacting with DNA in pinealocytes to upregulate melatonin synthesis enzymes (AANAT, HIOMT). Research suggests applications in circadian rhythm disorders, insomnia, age-related melatonin decline, and neuroprotection through restored melatonin signaling.
Pinealon interacts with DNA regulatory elements in pinealocytes, upregulating enzymes involved in melatonin biosynthesis from serotonin. It normalizes circadian clock gene expression and enhances nocturnal melatonin peaks.
Circadian rhythm restoration. Age-related melatonin decline. Sleep disorders. Neuroprotection via melatonin pathway.
Pineal gland support, Circadian rhythm, Sleep regulation
Minimal reported
