Pinealon

Also known as: Pineal Gland Bioregulator

Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed as a pineal gland bioregulator by the Khavinson group. It is designed to normalize melatonin synthesis and circadian rhythm function. Preclinical studies demonstrate that pinealon can penetrate cell membranes and nuclear membranes, interacting with DNA in pinealocytes to upregulate melatonin synthesis enzymes (AANAT, HIOMT). Research suggests applications in circadian rhythm disorders, insomnia, age-related melatonin decline, and neuroprotection through restored melatonin signaling.