P21 molecular structure
P21 molecular structure
Experimental
🧠Cognitive & Nootropic

P21

Also known as: CNTF Peptide

Routes

2 routes

P21 (also called Cerebrolysin-derived peptide P021) is a small tetrapeptide derivative (Ac-DGGL) based on an active region of ciliary neurotrophic factor (CNTF) that promotes neurogenesis and inhibits neurodegeneration. Unlike full-length CNTF, P21 is orally bioavailable and crosses the blood-brain barrier. Preclinical studies show it enhances dentate gyrus neurogenesis, reduces tau pathology, and improves cognitive function in Alzheimer's disease models through dual mechanisms: BDNF/TrkB upregulation and GSK-3β inhibition.

Research Use Only— For educational and research purposes only

Research Applications

Alzheimer's disease (preclinical). Adult neurogenesis enhancement. Tau pathology reduction. Cognitive decline prevention.

Mechanism of Action

P21 increases BDNF expression through CNTF receptor (CNTFR/LIFRβ/gp130) signaling. It inhibits leukemia inhibitory factor (LIF) signaling, relieving its suppression of neurogenesis. P21 also inhibits GSK-3β, reducing tau hyperphosphorylation and promoting β-catenin-mediated neurogenesis.

Biological Pathways

Neurogenesis, Cognitive enhancement, Neuroprotection

Dosage Information

Typical dosage ranges for research applications. Always verify with current literature.
Typical Dose
250 mcg
Dose Range
100 - 500 mcg
Frequency
Once daily, 4-6 week cycles; start 100-250 mcg weeks 1-3
Dosage Calculator
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Dosage calculation parameters
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Calculation Results

Concentration
2.5 mg/ml
Dose Volume
0.1 ml0.100 ml
Insulin Syringe
10 units
Doses per Vial
2020 doses @ 250 mcg

Syringe Fill Level (100u syringe)

05010010.0uunits
0u10.0 / 100 units (10%)100u

Protocols

No protocols featuring this peptide yet.

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Regulatory Status

Experimental

Very limited human data. Experimental compound

Research Studies

P21 Promotes Neurogenesis and Reduces Tau Pathology

Bolognin S, Buffelli M, Bhatt N, et al.

Neurobiology of Aging
2014
View Source
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