Research Applications
Reproductive endocrinology diagnostics. Hypothalamic amenorrhea treatment. IVF protocol optimization. Pubertal disorder research.
Mechanism of Action
Kisspeptin-10 binds GPR54 (KISS1R), a Gq-coupled GPCR on GnRH neurons. Activation triggers PLC/IP3-mediated calcium release, depolarizing GnRH neurons and stimulating pulsatile GnRH secretion. This drives LH and FSH release from anterior pituitary gonadotrophs.
Dosage Information
Calculation Results
Syringe Fill Level (100u syringe)
Protocols
No protocols featuring this peptide yet.
Browse All ProtocolsResearch Studies
Kisspeptin and the Regulation of Reproduction
Dhillo WS, Chaudhri OB, Patterson M, et al.
Frequently Asked Questions
Kisspeptin-10 is the biologically active C-terminal decapeptide fragment of the 54-amino acid kisspeptin-54, both encoded by the KISS1 gene. It binds to the kisspeptin receptor (GPR54/KISS1R) on GnRH neurons in the hypothalamus, serving as the master regulator of the reproductive axis. Kisspeptin-10 is the most potent known stimulator of GnRH and consequently LH/FSH release. Clinical applications include diagnostic evaluation of reproductive disorders and potential therapeutic use for hypothalamic amenorrhea and IVF protocols.
Kisspeptin-10 binds GPR54 (KISS1R), a Gq-coupled GPCR on GnRH neurons. Activation triggers PLC/IP3-mediated calcium release, depolarizing GnRH neurons and stimulating pulsatile GnRH secretion. This drives LH and FSH release from anterior pituitary gonadotrophs.
Reproductive endocrinology diagnostics. Hypothalamic amenorrhea treatment. IVF protocol optimization. Pubertal disorder research.
