Cortagen molecular structure
Cortagen molecular structure
Experimental
🧠Cognitive & Nootropic

Cortagen

Also known as: Brain Bioregulator

MW

390.40 Da

Routes

1 route

Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Pro) bioregulator targeting cerebral cortex function, developed by the Khavinson group. It is designed to normalize neuronal function in the cerebral cortex by modulating gene expression related to neurotransmitter synthesis, synaptic plasticity, and neuroprotection. Preclinical studies show improved cognitive function, enhanced memory, and neuroprotective effects in models of cerebral ischemia and age-related cognitive decline.

Research Use Only— For educational and research purposes only

Research Applications

Cognitive decline and cerebral cortex function normalization. Stroke recovery. Age-related neurodegeneration.

Mechanism of Action

Cortagen penetrates the nuclear membrane and interacts with DNA regulatory regions in cortical neurons, modulating transcription of genes involved in neurotransmitter metabolism, synaptic protein synthesis, and anti-apoptotic pathways.

Biological Pathways

Cognitive function, Brain health

Dosage Information

Typical dosage ranges for research applications. Always verify with current literature.
Typical Dose
500 mcg
Dose Range
100 - 1,000 mcg
Frequency
Daily for 10-20 day cycles, 2-4 cycles per year
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Calculation Results

Concentration
2.5 mg/ml
Dose Volume
0.1 ml0.100 ml
Insulin Syringe
10 units
Doses per Vial
2020 doses @ 250 mcg

Syringe Fill Level (100u syringe)

05010010.0uunits
0u10.0 / 100 units (10%)100u

Protocols

No protocols featuring this peptide yet.

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Side Effects & Precautions

Minimal reported

Research Use Only. This information is for educational and research purposes only. Not intended for medical advice or self-medication.

Research Studies

Peptide Bioregulators of the CNS

Khavinson VK, Malinin VV.

Bulletin of Experimental Biology and Medicine
2004
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