A side-by-side reading of TB-500 and Thymosin Beta-4 from our profiles: origin, mechanism, studied uses and evidence status. No recommendations — only what the sources say.
Key parameters side by side
Parameter
TB-500
Thymosin Beta-4
Category
Tissue Repair
Tissue Repair
Evidence status
Clinical Trial
Experimental
Sequence length
—
—
Molecular weight
4963.44 Da
4963.44 Da
Tissue Repair
TB-500
Clinical Trial
TB-500 is a synthetic version of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid peptide present in virtually all human and animal cells. Originally isolated from the thymus gland, Thymosin Beta-4 is the most abundant member of the beta-thymosin family and plays fundamental roles in cell migration, wound healing, and tissue repair through its primary function as a major actin-sequestering protein.
TB-500 contains the full Thymosin Beta-4 sequence with the critical active domain centered around the actin-binding motif LKKTETQ (amino acids 17-23), which is responsible for the peptide's ability to promote cell migration, angiogenesis, and tissue regeneration. Unlike many peptides, TB-500's mechanisms operate across virtually all tissue types — from cardiac and skeletal muscle to skin, cornea, and neural tissue.
The peptide has generated substantial research interest for its therapeutic potential in wound healing, cardiac repair following myocardial infarction, neurological recovery, and musculoskeletal injury. It is widely used in equine and veterinary medicine for tissue repair. TB-500 is not approved for human clinical use and is prohibited by WADA.
Thymosin Beta-4 (Tβ4) is a 43-amino acid, naturally occurring peptide and the most abundant member of the beta-thymosin family. Originally isolated from the thymus gland, Tβ4 is found in virtually all nucleated cells and is particularly concentrated in blood platelets, wound fluid, and developing tissues. It is the endogenous form of TB-500 and serves as the primary intracellular G-actin sequestering protein, fundamentally regulating cytoskeletal dynamics.
Tβ4 plays essential roles in embryonic development (cardiac, vascular, and neural morphogenesis) and adult tissue repair. Its central actin-binding motif LKKTETQ drives cell migration, angiogenesis, and wound healing across virtually all tissue types. RegeneRx Biopharmaceuticals has advanced Tβ4 through clinical trials for cardiac repair, wound healing, and ophthalmological applications, making it one of the most clinically studied regenerative peptides.
TB-500 is a synthetic version of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid peptide present in virtually all human and animal cells. Originally isolated from the thymus gland, Thymosin Beta-4 is the most abundant member of the beta-thymosin family and plays fundamental roles in cell migration, wound healing, and tissue repair through its primary function as a major actin-sequestering protein.
TB-500 contains the full Thymosin Beta-4 sequence with the critical active domain centered around the actin-binding motif LKKTETQ (amino acids 17-23), which is responsible for the peptide's ability to promote cell migration, angiogenesis, and tissue regeneration. Unlike many peptides, TB-500's mechanisms operate across virtually all tissue types — from cardiac and skeletal muscle to skin, cornea, and neural tissue.
The peptide has generated substantial research interest for its therapeutic potential in wound healing, cardiac repair following myocardial infarction, neurological recovery, and musculoskeletal injury. It is widely used in equine and veterinary medicine for tissue repair. TB-500 is not approved for human clinical use and is prohibited by WADA.
Thymosin Beta-4 (Tβ4) is a 43-amino acid, naturally occurring peptide and the most abundant member of the beta-thymosin family. Originally isolated from the thymus gland, Tβ4 is found in virtually all nucleated cells and is particularly concentrated in blood platelets, wound fluid, and developing tissues. It is the endogenous form of TB-500 and serves as the primary intracellular G-actin sequestering protein, fundamentally regulating cytoskeletal dynamics.
Tβ4 plays essential roles in embryonic development (cardiac, vascular, and neural morphogenesis) and adult tissue repair. Its central actin-binding motif LKKTETQ drives cell migration, angiogenesis, and wound healing across virtually all tissue types. RegeneRx Biopharmaceuticals has advanced Tβ4 through clinical trials for cardiac repair, wound healing, and ophthalmological applications, making it one of the most clinically studied regenerative peptides.