Research Use Only
This information is for educational and research purposes only. Not intended for medical advice or self-medication.
Overview
Protocol for restoring cellular NAD+ levels using one of three interchangeable approaches: direct NAD+ administration, NMN supplementation, or Nicotinamide Riboside (NR). Choose ONE approach based on your budget, preferred route, and goals. NAD+, NMN, and NR all raise NAD+ levels — they are alternatives, not a stack. NAD+ levels decline ~50% between ages 40-60, contributing to aging, cognitive decline, and metabolic dysfunction. Restoring NAD+ supports DNA repair, mitochondrial function, sirtuin activation, and cellular energy production.
Peptides Involved
Compare the peptides included in this protocol side by side.
| Typical Dose | |||||
|---|---|---|---|---|---|
| NAD+ | Approved | ⏳Longevity | — | 500 mcg 1-4 sessions per week in clinical settings | |
| NMN | Approved | ⏳Longevity | 334.22 Da | 500 mcg Once daily, preferably in the morning | |
| Nicotinamide Riboside | Approved | ⏳Longevity | 255.25 Da | 500 mcg Once or twice daily with food |
Comparing 3 peptides
Dosage Schedule
Option A (NMN oral — most popular): 250-500 mg daily in the morning. Option B (NR oral — best researched): 250-500 mg daily with food. Option C (NAD+ injection — most potent): 50-100 mg subcutaneous 1-2x/week. Option D (NAD+ IV — clinical setting): 250-500 mg infusion 1x/week.
Daily for oral supplements (NMN/NR), 1-3x per week for injections (NAD+)
Cycle Information
No cycling required for oral NMN/NR. For NAD+ injections: some practitioners recommend 4 weeks on, 1 week off. Loading phase option: higher doses for 7-10 days initially, then maintenance.
Stacking Notes
Recommended additions: Resveratrol (500-1000 mg) — activates sirtuins that depend on NAD+. TMG / Trimethylglycine (500-1000 mg) — replenishes methyl donors depleted by NAD+ metabolism. Do NOT combine multiple NAD+ precursors (e.g. NMN + NR) — choose one. Can be combined with other longevity peptides (Epithalon, MOTS-c) in broader anti-aging protocols.
Peptides in this stack::
Warnings & Precautions
Consult a physician before starting, especially with cancer history (NAD+ may theoretically support cancer cell proliferation). Avoid during pregnancy/breastfeeding. NAD+ IV infusion may cause temporary flushing, nausea, or headache — slow infusion rate helps. Start with lower doses to assess individual tolerance.
Research Use Only. This information is for educational and research purposes only. Not intended for medical advice or self-medication.