Epobis molecular structure
Epobis molecular structure
Experimental
💪Tissue Repair

Epobis

Also known as: EPO mimetic

MW

2500.00 Da

Routes

1 route

Epobis is a peptide derived from erythropoietin (EPO) that retains the tissue-protective and cytoprotective properties of EPO without stimulating erythropoiesis (red blood cell production). Like ARA 290, it targets the innate repair receptor (EPOR/βcR heterodimer) rather than the classical erythropoietic EPOR/EPOR homodimer. Preclinical research demonstrates neuroprotective, cardioprotective, and anti-inflammatory effects mediated through JAK2/STAT5 and PI3K/Akt survival signaling pathways. This approach separates EPO's beneficial tissue-protective effects from its potentially dangerous erythropoietic effects (thrombosis risk with elevated red blood cells).

Research Use Only— For educational and research purposes only

Research Applications

Neuroprotection in stroke and TBI. Cardioprotection. Anti-inflammatory therapy. Tissue repair without erythropoiesis.

Mechanism of Action

Activates the tissue-protective EPOR/βcR receptor complex, engaging JAK2/STAT5, PI3K/Akt, and NF-κB anti-inflammatory signaling without activating the erythropoietic EPOR homodimer.

Dosage Information

Typical dosage ranges for research applications. Always verify with current literature.
Frequency
Research: 10 mg/kg SC daily for 5 days (preclinical, animal models only)
Weight-Based
10000 mcg/kg
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Calculation Results

Concentration
2.5 mg/ml
Dose Volume
0.1 ml0.100 ml
Insulin Syringe
10 units
Doses per Vial
2020 doses @ 250 mcg

Syringe Fill Level (100u syringe)

05010010.0uunits
0u10.0 / 100 units (10%)100u

Protocols

No protocols featuring this peptide yet.

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Research Studies

Non-Erythropoietic EPO Derivatives for Tissue Protection

Brines M, Cerami A.

Kidney International
2006
View Source
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